Vy Vy House is in District 1, the historic centre of Ho Chi Minh City, where cafés, bars and eateries sit close together. Within 50 m are the temples Đình Ông Quan Thánh and Chùa Phước Hậu, and the Bui Vien street, known for its bars and backpacker crowds, is close by. The Nam Thành Holy See church is 300 m away, and the Saigon Evangelical Church is 350 m. The nearest restaurants and bars are all within 50 m.
Two bus stations are nearby: Bến xe buýt Sài Gòn is 250 m away and Bến xe Sài Gòn is 300 m away, so anyone with a light bag can walk from either one. Saigon Railway Station is 2.3 km away, and Tan Son Nhat International Airport is 5.5 km, a distance that makes a taxi or car the practical choice for both.
On foot, Thai Binh Market is 250 m away and Ben Thanh Market, the best-known of the central markets, is 1 km away. Ben Thanh Station is 900 m away, the Ho Chi Minh City Fine Arts Museum 950 m, and Tao Dan Park 900 m, while the War Remnants Museum is 1.4 km away. The Vietnam History Museum is 2.8 km away. Nha Rong Wharf, on the river, lies 1.7 km off. For a longer walk, the Saigon River Tunnel is 2 km away and the Zoo and Botanical Garden Ho Chi Minh is 2.9 km. The Fine Arts Museum, the War Remnants Museum and Tao Dan Park can be combined in one day, all within 1.4 km of the property.